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"Hotel Iroquois, Buffalo, 1900." The ectoplasmic pedestrians are out in force. 8x10 inch dry plate glass negative, Detroit Publishing Company. View full size.
Bliss Brothers (Harry A. and Frank H.) are sons of Horace L. Bliss, one of the oldest living photographers in Buffalo. He was born in Hartford, Conn., October 6, 1823, came to Buffalo about 1854 and learned the photographic business. In 1859 he established a photograph gallery at the corner of Main and Eagle streets, and successfully continued until 1886, when he retired on account of ill health. He made a specialty of outside photographs and also did considerable commercial work. Harry A. and Frank H. Bliss are natives of Buffalo; the former was born February 28, 1866, and the latter February 6, 1858. Both were educated in the Buffalo public and high schools, learned photography with their father, and when the latter retired in 1886 succeeded him in business under the firm name of Bliss Brothers. Soon after starting, their portrait and commercial work had grown to such proportions that they separated the two, locating the latter on Oak street near Genesee, and continuing the former at the corner of Main and Eagle streets. They are among the leaders in both branches in Buffalo, and enjoy the highest reputation for artistic work.
Some things seem to stay the same. The lady on the near corner appears to have done a 180 when she may have perhaps noticed a shoe sale sign in the store window.
A double dose would be required for crybabies like myself when occupying the dentist's chair.
[Active ingredient: Cocaine. - Dave]

Thought this one looked familiar. Just a bit of a different angle from This thread.
[Also a different year, different storefronts, different signage! - Dave]
Is the circus in town? There is a two-headed cyclist in front of the hotel.
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