September 1938. "Coal miner's children and wife, Pursglove, West Virginia." 35mm nitrate negative by Marion Post Wolcott for the FSA. View full size.

1942 or 1943. "Gilead, Ohio (?), possibly Mount Gilead" is the uncertain caption. Although the photo does provide a few clues. 35mm Kodachrome transparency by John Vachon for the Farm Security Administration. View full size.

UPDATE: A couple of astute commenters have identified this as a building on Main Street in Mount Orab, Ohio. Google Street View gives a pretty good match. If there are any Shorpyite shutterbugs in Mount Orab, hie on over to the intersection of Main and High, send us some pics and help us lay to rest a mystery that's been bedeviling the Library of Congress for the past 65 years!

City Point, Virginia, circa 1865. "Rear view of General Grant's headquarters." Photos from the main Eastern theater of war, the siege of Petersburg, June 1864- April 1865. Wet plate glass negative, photographer unknown. View full size.

"Miss Adrianne Henderson, 1939." Harris & Ewing glass negative. View full size.

"Hancock's, the Old Curiosity Shop, 1234 Pennsylvania Avenue," probably around 1914, the final year of its existence. The restaurant, the Washington Post reported in 1927, "was noted particularly for two things -- its cocktails and its fried chicken." Harris & Ewing Collection glass negative. View full size.

New York, February 1912. "The breaking point. A heavy load for an old woman. Lafayette Street below Astor Place." Photo by Lewis Hine. View full size.

February 1942. Akron, Ohio. Firestone Rubber. "Conversion. Beverage containers to aviation oxygen cylinders. After shatterproof oxygen cylinders for high altitude flying have passed all tests in the metal division of a large Eastern rubber factory, hot air is blown through the cylinders to remove all trace of moisture. The cylinders are then sealed and stacked for painting." 4x5 nitrate negative by Alfred Palmer for the Office of War Information. View full size.