This building still exists at 6 North Brooks Street in Manning, SC. If the brickwork over the sign and the fancy pilasters weren't enough to identify it, the two white lines on the store at left are a dead giveaway.

ETA: The Manning Times has moved to 416 West Boyce Street since Google Earth passed through the area.

In the top right corner is a glass globe type lighted sign says St. Pe---- at the top and No.54 AF& -- on the bottom. St. Peters Lodge #54 AF&AM (Ancient free and accepted Masons) masonic lodge located at 232 E. Boyce, Manning, SC 29102

[Another clue: MANNING CANDY. - Dave]

The wiring to the Budweiser sign caught my eye. A pair of wires emanate from the building about where the "r" is in "Drink", runs across the front where one wire disappears under the awning and re-emerges, presumably for a switch. I wonder if it is in series with the bulb hanging down above the girl. That would be a strange way to do things but I've noticed in many other Shorpy images that they were very casual about electrical wiring back then.