The tower at the far end seems to be the Wrigley Building - South Tower 400 N Michigan Ave located on the Magnificent Mile. This year it had his hundredth aniversary as it had been completed in April 1921.

I thought this was the Drake Hotel but yup, Hilton.

Michael R is correct. Even the glass fronted building on the next block appears to have the original stone façade behind it.

This view of South Michigan Avenue is taken from just south of Balbo Drive (formerly known as 7th Street) looking north. The hotel now called the Hilton Chicago, originally called the Stevens Hotel, is shown at the far left. For my generation of Chicagoans, it will always be known as the Conrad Hilton, especially for its role in the riots during the Democratic National Convention in 1968. Just across the street to the right is the Blackstone Hotel. This hotel has its own notoriety in American political history: it was the location of the original "smoke-filled room" at the Republican Convention of 1920, where Warren G. Harding was chosen to run for President. With very few exceptions, all the buildings shown in this photo are still standing.