From The Trained Nurse & Hospital Review January 1913 via Google Book View

Also in this picture, on the right, in the row of stores is a Schrafft's Restaurant. It was one of a chain of 8 or so upscale restaurants in NYC. I have a recollection of the one at 13 Street and 5th Avenue in the attached picture. Sometime in the 1950s a friend invited to me to lunch there. It was a hot summer's day and we were in shirtsleeves. They wouldn't let us in without jackets. After some negotiating they supplied jackets for us to wear. They were the ones their waiters wore. The building (in the attachment) later become the Lone Star Cafe which was very popular. The building is located in what could be loosely described as the New School's Parsons Campus. It has become Condominium Apartments.

You are right History_Fan, that is the back of the Anheuser Busch famous "A & Eagle", makers of Budweiser & Michelob. I've found some great beer signs on Shorpy's, some in plain view and others almost invisible. All are a lot of fun to search for.

Look just above and to the left of the Regal shoes sign. Is that the back side of a Budweiser sign?

Is that a restaurant just for ladies or is that the ladies entrance? Either way, it's intriguing.

[It indicated that the establishment was one which respectable women could patronize unescorted without fearing for their safety or reputation. - tterrace]

Opened in 1888. During the years when Broadway theaters were concentrated south of Times Square, "many of our popular actors made it their home."

"It will go down in history as one of the famous Broadway hostelries of pre-Volstead days ..."

According to an ad that ran often in the Atlanta Constitution around 1900, "The Hotel Marlborough ... is very popular with the southern people ... The rooms are beautifully carpeted in brussels and velvet, while the furniture in them is of the handsomest character...A lady can leave the south and travel all the way to New York and stop at the Marlborough with as much propriety and safety as if she were at the best hotel in her own town."

But a 1923 picture in the NYTimes made it look a bit seedy. A large sign offered "ROOMS WITH BATH $1.50/UP"

In 1923 the building was purchased by A.E. Lefcourt, one of NYC's most prominent developers who erected the Brill Building, among many others.

Lefcourt planned to erect a 20-story office and loft building to cost $3 million for buyers in the women's garment and millinery industry, which apparently had by then replaced the theaters.